Smoking, the xenobiotic pathway, and clubfoot
نویسندگان
چکیده
منابع مشابه
The Retinoblastoma Tumor Suppressor Regulates a Xenobiotic Detoxification Pathway
The retinoblastoma tumor suppressor (pRb) regulates cell cycle entry, progression and exit by controlling the activity of the E2F-family of transcription factors. During cell cycle exit pRb acts as a transcriptional repressor by associating with E2F proteins and thereby inhibiting their ability to stimulate the expression of genes required for S phase. Indeed, many tumors harbor mutations in th...
متن کاملThe Neglected Clubfoot
The neglected clubfoot deformity is a major disabler of children and adults in developing nations. The bones and joints of the foot deform into fixed equinus, adductus, cavus, and supination as patients walk on the side or dorsum of the foot. There is severe obliquity of the calcaneocuboid joint, which must be corrected in most cases. An algorithmic surgical approach, using peritalar soft tissu...
متن کاملThe steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian species and SXR exhibits considerable differ...
متن کاملInteractions between Cigarette Smoking and Polymorphisms of Xenobiotic-Metabolizing Genes: The Risk of Oral Leukoplakia
BACKGROUND This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). METHODS The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age...
متن کاملFamily history, maternal smoking, and clubfoot: an indication of a gene-environment interaction.
Although epidemiologic studies of some birth defects have suggested a gene-smoking interaction, the possibility of this interaction in clubfoot has not been examined. The authors analyzed risk factors among 346 infants with isolated clubfoot and 3,029 infants without defects from the Atlanta Birth Defects Case-Control Study. All infants were born during 1968-1980, and mothers were interviewed i...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2010
ISSN: 1542-0752
DOI: 10.1002/bdra.20742